Rhubarb is a well known ancient superfood. Obesity and obesity-related disorders, like metabolic syndrome and type 2 diabetes have been progressively increasing worldwide and prescribed medication treatments with the adverse effects have failed to counteract their progression. Various plant-derived substances have been extensively studied as a promising support or even an alternative for existing anti-obesity therapies. Significance of the Rhubarb-based preparation as an extract in a context of the anti-obesity action still remains only partly recognized by the medical community.
 
The history of Rhubarb began in China, Siberia, the Himalayas, and Mongolia. Rhubarb root can survive even on frozen grounds. Rhubarb stalk was used for medicinal purposes. Rhubarb is an important Chinese medicinal herb and has been commonly used as far back since  2700 B.C. It is a vegetable. In fact, Rhubarb has been utilized for many years and it is only in recent times people started to use it as food. In fact, the first time Rhubarb was featured and used in a recipe was in 1806 or 1807, and it was used in making a rhubarb tart.
 
Rhubarb Extract exert it's effects through several mechanisms, including increased lipolysis (fat breakdown), changes in gut microbiota composition, and potentially increased energy expenditure.
 
Growing evidence demonstrates that gut microbiota is associated with the incidence of these pathologies. Hence, herbal nutritional compounds, able to improve health through a modulation of gut microbiota, is of great and gaining interest. In this context, the aim of this study was to investigate the gut-driving effects of Rhubarb extract in a context of diet-induced obesity and diabetes.
 
Rhubarb Extract supplementation fully prevented HFHS-induced obesity, diabetes, visceral adiposity, adipose tissue inflammation and liver triglyceride accumulation, without any modification in food intake. By combining sequencing and qPCR methods, we found that all these effects were associated with a blooming of Akkermansia muciniphila, which is strongly correlated with increased expression of Reg3γ (Regenerating islet-derived protein 3 gamma (Reg3γ) is an antimicrobial peptide primarily expressed by intestinal epithelial cells (IECs). It plays a crucial role in maintaining intestinal health, regulating gut microbiota, and preventing bacterial translocation. Reg3γ acts as an antimicrobial by binding to peptidoglycan in Gram-positive bacteria, leading to bactericidal activity.) in the colon. Data shows that Rhubarb Extract supplementation is sufficient to protect against metabolic disorders induced by a diet rich in lipid and carbohydrates in association with a reciprocal interaction between Akkermansia muciniphila and Reg3γ - healthy gut microbiome activity.
 
Rhubarb Extract supplementation is sufficient to protect against metabolic disorders induced by a diet rich in lipid and carbohydrates in association with a reciprocal interaction between Akkermansia muciniphila and Reg3γ.
 
Rhubarb Extract Prevents Obesity and Fat Mass Accumulation in animal and human studies. Improving gut flora & the intestinal microbiome related to metobolic disease. 
Rhubarb Extract Blunts Glucose Intolerance, Hepatic Steatosis and Liver Inflammation.
Rhubarb Extract Protects Against Adiposity and Adipose Tissue Inflammation.
Rhubarb Extract IMPROVES Antimicrobial Peptides and Intestinal Renewal.
Rhubarb Extract effects on Gut Microbiota Composition Are Impressive.
Rhubarb Extract is a  Liver champion - In traditional folk medicine, rhubarb is used to improve liver health & modern studies show it  helps with this. In studies of people with non-alcoholic fatty liver disease, rhubarb helped to reduce the symptoms.

In traditional folk medicine, rhubarb is used to improve liver health and some modern studies show it might, indeed, help with this. In a study of people with non-alcoholic fatty liver disease, rhubarb helped to reduce the symptoms
Rhubarb Extract Promotes the Growth of Akkermansia muciniphila the best friendly flora found in the gut - this friendly bacteria is responsible for metabolic improvements including contributing to reinforce the gut barrier function.
Source: Rhubarb Supplementation Prevents Diet-Induced Obesity and Diabetes in Association with Increased Akkermansia muciniphila -
https://pmc.ncbi.nlm.nih.gov/articles/PMC7601677/ 
 
Conclusion: "The efficacy of Rhubarb Extract in treating simple obesity was similar to that of fenfluramine, but the side-effect was obviously less than that of fenfluramine, while the markedly effective rate and effective rate of Rhubarb Extract in slimming were significantly better than that of the drug." 
source: Clinical study on Rhubarb Extract in treating simple obesity - 
https://link.springer.com/article/10.1007/BF02935106
 
source: A Review on Rhubarb-Derived Substances as Modulators of Cardiovascular Risk Factors—A Special Emphasis on Anti-Obesity Action - https://www.mdpi.com/2072-6643/14/10/2053
 
Akkermansia muciniphila is a healthy gut friendly microbe beneficial  to the Gut Immune System: A Good Friendship That Attenuates Inflammatory Bowel Disease, Obesity, and Diabetes - The incidence of this friendly flora has been proven to increase with Rhubarb Extract supplementation.
 
Rhubarb Extract can be used as a holistic tool as part of a comprehensive weight management approach, which may include dietary changes, exercise, and other lifestyle modifications
 
Ingredients:
A double-infused tradtional, old world herbalist strength functional food extract. 
Organic Canadian Local or our Farm Grown Rhubarb 1:1 ratio, gluten free organic alcohol
 
120 ml glass dropper bottle