Pine Needle Extract - Eastern White Pine - Wildcrafted

Eastern White Pine needles contain Shikimate (Shikimic Acid), and a slew of other meta nutrients which boost immunity, hydrate, and contribute to the dismantling of Graphene Oxide Nanoparticles at a cellular level. Conifer needle infusions- extracts inhibit adverse reactions from graphene oxide and Covid-19 spike protein transmission and protect against components of the coagulation cascade; possibly protecting against blood clots. Pine also inhibits the inappropriate replication and modification of RNA and DNA.Source: https://bit.ly/3IsZ5oI

Source: - https://go.nature.com/3wOZrg3

Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin -

Suramin Inhibits SARS-CoV-2 Infection in Cell Culture by Interfering with Early Steps of the Replication Cycle - Source; https://bit.ly/3ksHh13 - ASM Journals
Antimicrobial Agents and Chemotherapy
Vol. 64, No. 8

Suramin in Pine Needles -
Suramin is naturally found in Eastern White Pine needles.

As a matter of fact, pine needles are the best natural source of suramin. Here’s why.

One of the benefits of using whole herbs instead of isolated extracts is that a herb is much more complex mix of chemistry that has just the right amount of different substances that work together, resulting in a bigger effect than all the substances individually.

Suramin as medication is used to treat African sleeping sickness and river blindness. Eastern White Pine needles represent a suramin natural alternative, as this tree is the originating source of medicinal 'suramin' - so no great need to wonder where to get suramin.

Suramin pine needles benefits are believed to be particularly helpful for blood clots, protecting your DNA and RNA, while antioxidants, also found in pine needles, help protect your heart, brain, liver, and other organs."

" Effects of suramin on complement, blood clotting "- Source - https://bit.ly/3ewFAMl

"Suramin, which has recently been under investigation as a cancer chemotherapeutic agent, has previously been found to induce heparin-like anticoagulants in treated patients. In the currently reported work suramin is shown to have an additional anticoagulant activity that is due to direct effects of the drug on procoagulant proteins. " Source: - https://bit.ly/3exq2I2

 

SURAMIN, THE FRUIT OF EARLY MEDICINAL CHEMISTRY: Suramin is a derivative of the oils in White Pine needles. "Suramin further decreases the activities of a large number of enzymes involved in DNA and RNA synthesis and modification: DNA polymerases (103, 104), RNA polymerases (103, 105, 106), reverse transcriptase (18, 103), telomerase (67), and enzymes involved in winding/ unwinding of DNA (107, 108) are inhibited by suramin, as well as histone- and chromatin - modifying enzymes like chromobox proteins (109), methyltransferases (110), and sirtuin histone deacetylases (111)."

"The whole herbal source (white pine needles) is superior to the single compound drug (Suramin) – because the needles possess a full complement of phytonutrients providing numerous additional benefits that the drug is incapable of."
Source: - https://go.nature.com/3iwbOJv

A compound found in pine needles, which was isolated and chemically copied is a drug by prescription named  "suramin" & has been identified as a potential antidote to the current spike protein contagion resulting from the chimeric SARS-CoV-2 coronavirus, and the potential pathogenic transmission of the spike protein from the experimental mRNA vaccines.

Suramin precursor compounds can be naturally obtained as an alcohol extract from Eastern White Pine tree needles (Pinus Strobus). Among other beneficial constituents of eastern white pine tree needles are Alpha-Pinene, Beta-Pinene, Beta-Phellandrene, D-Limonene, Germacrene D, 3-Carene, Caryophyllene, vitamin A, and vitamin C. Eastern white pine needles also contain shikimic acid, used historically in Traditional Chinese Medicine to treat plagues and respiratory illness.

Pine needles have been used by indigenous populations around the world as both food and medicine for thousands of years. Fresh pine needles from eastern white pine trees and other appropriate trees have been used for centuries as sources of vitamin C and other phytochemicals that Native Americans used to treat respiratory infections and other ailments. Vitamin C is a known cure for scurvy, as scurvy is a disease of vitamin C deficiency. Pine needles contain many other substances that appear to reduce platelet aggregation in the blood, potentially preventing blood clots that lead to strokes, heart attacks, and pulmonary embolism diagnoses.

Mechanism Identified Whereby Suramin Inhibits SARS-CoV-2 RdRp

Thus, research shows that suramin is a direct and potent viral RdRp inhibitor by direct inhibition, with structural analysis showing the mechanism of binding and inhibition.

Not only has suramin from pine needles been used traditionally for viruses and parasites, but suramin-based drugs have been extensively tested as a treatment for several types of cancers..

The inhibitory effect of suramin sourced from eastern white pine needles on the coronavirus spike protein, Zika and Chikungunya viruses, and certain parasites warrant further evaluation of this naturally occurring compound as a potential broad-spectrum therapeutic food.

References

1. Xu, H. Eric, Wanchao Yin, Xiaodong Luan, Zhihai Li, Leike Zhang, Ziwei Zhou, Minqi Gao et al. "Structural basis for repurposing a 100-years-old drug suramin for treating COVID-19." (2020).

2. Yin, W. et al. (2020). Structural Basis For Repurposing A 100-Years-Old Drug Suramin For Treating COVID-19. bioRxiv preprint. doi: https://doi.org/10.1101/2020.10.06.328336. https://www.biorxiv.org/content/10.1101/2020.10.06.328336v1

3. Salgado-Benvindo, C. et al. Suramin Inhibits SARS-CoV-2 Infection in Cell Culture by Interfering with Early Steps of the Replication Cycle. Antimicrob Agents Chemother 64(2020)

4. Albulescu, I.C., Kovacikova, K., Tas, A., Snijder, E.J., and van Hemert, M.J. (2017). Suramin inhibits Zika virus replication by interfering with virus attachment and release of infectious particles. Antiviral Res 143, 230-236.

5. Henß, L. et al. Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry. Virol J 13, 149 (2016).

6. Ren, P., Zou, G., Bailly, B., Xu, S., Zeng, M., Chen, X., Shen, L., Zhang, Y., Guillon, P., Arenzana-Seisdedos, F., et al. (2014). The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection-suramin inhibits EV71 infection in vitro and in vivo. Emerging microbes & infections 3, e62.

7. Albulescu, I.C., van Hoolwerff, M., Wolters, L.A., Bottaro, E., Nastruzzi, C., Yang, S.C., Tsay, S.-C., Hwu, J.R., Snijder, E.J., and van Hemert, M.J. (2015). Suramin inhibits chikungunya virus replication through multiple mechanisms. Antiviral Research 121, 39-46.

8. Zoltner, Martin, Gustavo D. Campagnaro, Gergana Taleva, Alana Burrell, Michela Cerone, Ka-Fai Leung, Fiona Achcar et al. "Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes." Journal of Biological Chemistry 295, no. 24 (2020): 8331-8347.

9. De Clercq, Erik. "Suramin in the treatment of AIDS: mechanism of action." Antiviral research 7, no. 1 (1987): 1-10.

10.Kartnig, Theodor, Franz Still, and Franz Reinthaler. "Antimicrobial activity of the essential oil of young pine shoots (Picea abies L.)." Journal of ethnopharmacology 35, no. 2 (1991): 155-157.

11.Croci, R., Pezzullo, M., Tarantino, D., Milani, M., Tsay, S.-C., Sureshbabu, R., Tsai, Y.-J., Mastrangelo, E., Rohayem, J., Bolognesi, M., et al. (2014). Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds. PloS one 9, e91765-e91765.

12.Cheng, B., Gao, F., Maissy, E., and Xu, P. (2019). Repurposing suramin for the treatment of breast cancer lung metastasis with glycol chitosan-based nanoparticles. Acta Biomater 84, 378-390.

13. Myers, Charles, Michael Cooper, Cy Stein, Renato LaRocca, M. M. Walther, Gary Weiss, Peter Choyke, Nancy Dawson, Seth Steinberg, and Margaret M. Uhrich. "Suramin: a novel growth factor antagonist with activity in hormone-refractory metastatic prostate cancer." Journal of clinical oncology 10, no. 6 (1992): 881-889.

14.Stein, C. A., R. V. LaRocca, R. Thomas, N. McAtee, and Charles E. Myers. "Suramin: an anticancer drug with a unique mechanism of action." Journal of Clinical Oncology 7, no. 4 (1989): 499-508.

15.Mooon, Jeong-jo, Young-bok Han, and Jin-suk Kim. "Studies on antitumor effects of pine needles, Pinus densiflora Sieb. et Zucc." Korean Journal of Veterinary Research 33, no. 4 (1993): 701-710.

16.Spigelman, Zachary, Amy Dowers, Susan Kennedy, Dennis DiSorbo, Michael O'Brien, Ronald Barr, and Ronald McCaffrey. "Antiproliferative effects of suramin on lymphoid cells." Cancer research 47, no. 17 (1987): 4694-4698.

17.Kathir, Karuppanan Muthusamy, Thallapuranam Krishnaswamy S. Kumar, and Chin Yu. "Understanding the mechanism of the antimitogenic activity of suramin." Biochemistry 45, no. 3 (2006): 899-906

18.https://pubchem.ncbi.nlm.nih.gov/compound/Suramin-sodium

19. Hosang, Markus. "Suramin binds to platelet‐derived growth factor and inhibits its biological activity." Journal of cellular biochemistry 29, no. 3 (1985): 265-273.

20. Betsholtz, Christer, Ann Johnsson, Carl-Henrik Heldin, and Bengt Westermark. "Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin." Proceedings of the National Academy of Sciences 83, no. 17 (1986): 6440-6444.

21. Coffey Jr, Robert J., Edward B. Leof, Gary D. Shipley, and Harold L. Moses. "Suramin inhibition of growth factor receptor binding and mitogenicity in AKR‐2B cells." Journal of cellular physiology 132, no. 1 (1987): 143-148.

22. Sartor, Oliver, Catherine A. McLellan, Charles E. Myers, and M. M. Borner. "Suramin rapidly alters cellular tyrosine phosphorylation in prostate cancer cell lines." The Journal of clinical investigation 90, no. 6 (1992): 2166-2174.

 

Eastern White Pine Tree Needles : A Natural Source of Anti-Infective Compounds:

"Several compounds found in Eastern White pine needles have been identified as a potential antidote to the current spike protein contagion resulting from the chimeric SARS-CoV-2 coronavirus, and the potential pathogenic transmission of the spike protein from the experimental mRNA vaccines.

Eastern white pine tree needles (Pinus Strobus) contain many beneficial constituents useful for the prevention of colds and flu such as Alpha-Pinene, Beta-Pinene, Beta-Phellandrene, D-Limonene, Germacrene D, 3-Carene, Caryophyllene, vitamin A, and vitamin C. Eastern white pine needles also contain shikimic acid, the same molecule found in star anise herb used historically in Traditional Chinese Medicine to treat plagues and respiratory illness.

Pine needles have been used by indigenous populations around the world as both food and medicine for thousands of years. Fresh pine needles from eastern white pine trees and other appropriate trees have been used for centuries as sources of vitamin C and other phytochemicals that Native Americans used to treat respiratory infections and other ailments. Vitamin C is a known cure for scurvy, as scurvy is a disease of vitamin C deficiency. Pine needles contain many other substances that appear to reduce platelet aggregation in the blood, potentially preventing blood clots that lead to strokes, heart attacks, and pulmonary embolism diagnoses.

The Compound Suramin

Suramin is strongly inhibitory to the replication of the coronavirus spike protein. It also has an inhibitory effect against components of the coagulation cascade and the inappropriate replication and modification of RNA and DNA. Excessive coagulation causes blood clots, mini-clots, strokes, and unusually heavy menstrual cycles, which are now being daily reported to VAERS post-vaccination. Recent research has shown it to be an in vitro inhibitor of SARS-CoV-2 infection in cell culture by preventing viral entry. Research shows this to be due to its potent inhibition of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), an essential viral lifecycle enzyme

Suramin originally is derived from trypan blue derived from toluene a derivative of pine oil.

When suramin was introduced for the treatment of African sleeping sickness in 1922, it was one of the first anti-infective agents that had been developed in a medicinal chemistry program. Starting from the antitrypanosomal activity of the dye trypan blue, synthesized in 1904 by Paul Ehrlich, Bayer made a series of colorless and more potent derivatives. Molecule 205 was suramin, synthesized by Oskar Dressel, Richard Kothe, and Bernhard Heymann in 1916. Pine needle oil was used as a botanical source for trypan blue. Sleeping sickness (also known as human African trypanosomiasis was at the forefront of research at that time, not a neglected disease as it is today, and the development of suramin was a breakthrough for the emerging field of chemotherapy.

Trypan blue is so-called because it can kill trypanosomes, the parasites that cause sleeping sickness. Trypan blue is derived from toluidine, that is, any of several isomeric bases, C14H16N2, derived from toluene. Trypan blue is also known as diamine blue and Niagara blue. Toluene is also a derivative of pine oil. The compound was first isolated in 1837 through a distillation of pine oil by the Polish chemist Filip Walter, who named it rétinnaphte.

Yet Eastern White pine needle extract / tincture provides a similar, if not superior, benefit, due in part to the fact that it is a direct mild extract of the whole herb leaving many of its properties still intact that might be destroyed by excessive heat during distillation and further dissection of its many nutrient components.

Mechanism Identified Whereby Suramin Inhibits SARS-CoV-2 RdRp

Thus, research shows that suramin is a direct and potent viral RdRp inhibitor by direct inhibition, with structural analysis showing the mechanism of binding and inhibition. This is the first non-nucleotide inhibitor of the SARS-CoV-2 RdRp, and this indicates the potential to develop suramin analogs and drug formulations as potent and effective inhibitors of viral replication.

Not only has suramin from pine needles been used traditionally for viruses and parasites, but suramin-based drugs have been extensively tested as a treatment for several types of cancers.

The inhibitory effect of suramin from pine needles on the coronavirus spike protein, Zika and Chikungunya viruses, and certain parasites warrant further evaluation of this naturally occurring compound as a potential broad-spectrum therapeutic. " 

Source: 

Sep 13 2021

Eastern White Pine Tree Needles: A Natural Source of Anti-Infective CompoundsJames Odell, OMD, ND, L.Ac.

https://www.biologicalmedicineinstitute.com/post/eastern-white-pine-tree-needles-a-natural-source-of-suramin

 

Eastern White Pine Tree Needles: A Natural Source of Anti-Infective Compounds : 

The Bioregulatory Medicine Institute (BRMI) was founded in 2017 as a noncommercial institute to increase public knowledge and integration of bioregulatory medicine as a wholistic, evidence-based medical system. We receive our non-profit status under fiscal sponsorship with independent funding to operate as a noncommercial and trusted source of unbiased, unfiltered, verified information.

References

1. Xu, H. Eric, Wanchao Yin, Xiaodong Luan, Zhihai Li, Leike Zhang, Ziwei Zhou, Minqi Gao et al. "Structural basis for repurposing a 100-years-old drug suramin for treating COVID-19." (2020).

2. Yin, W. et al. (2020). Structural Basis For Repurposing A 100-Years-Old Drug Suramin For Treating COVID-19. bioRxiv preprint. doi: https://doi.org/10.1101/2020.10.06.328336. https://www.biorxiv.org/content/10.1101/2020.10.06.328336v1

3. Salgado-Benvindo, C. et al. Suramin Inhibits SARS-CoV-2 Infection in Cell Culture by Interfering with Early Steps of the Replication Cycle. Antimicrob Agents Chemother 64(2020)

4. Albulescu, I.C., Kovacikova, K., Tas, A., Snijder, E.J., and van Hemert, M.J. (2017). Suramin inhibits Zika virus replication by interfering with virus attachment and release of infectious particles. Antiviral Res 143, 230-236.

5. Henß, L. et al. Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry. Virol J 13, 149 (2016).

6. Ren, P., Zou, G., Bailly, B., Xu, S., Zeng, M., Chen, X., Shen, L., Zhang, Y., Guillon, P., Arenzana-Seisdedos, F., et al. (2014). The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection-suramin inhibits EV71 infection in vitro and in vivo. Emerging microbes & infections 3, e62.

7. Albulescu, I.C., van Hoolwerff, M., Wolters, L.A., Bottaro, E., Nastruzzi, C., Yang, S.C., Tsay, S.-C., Hwu, J.R., Snijder, E.J., and van Hemert, M.J. (2015). Suramin inhibits chikungunya virus replication through multiple mechanisms. Antiviral Research 121, 39-46.

8. Zoltner, Martin, Gustavo D. Campagnaro, Gergana Taleva, Alana Burrell, Michela Cerone, Ka-Fai Leung, Fiona Achcar et al. "Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes." Journal of Biological Chemistry 295, no. 24 (2020): 8331-8347.

9. De Clercq, Erik. "Suramin in the treatment of AIDS: mechanism of action." Antiviral research 7, no. 1 (1987): 1-10.

10.Kartnig, Theodor, Franz Still, and Franz Reinthaler. "Antimicrobial activity of the essential oil of young pine shoots (Picea abies L.)." Journal of ethnopharmacology 35, no. 2 (1991): 155-157.

11.Croci, R., Pezzullo, M., Tarantino, D., Milani, M., Tsay, S.-C., Sureshbabu, R., Tsai, Y.-J., Mastrangelo, E., Rohayem, J., Bolognesi, M., et al. (2014). Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds. PloS one 9, e91765-e91765.

12.Cheng, B., Gao, F., Maissy, E., and Xu, P. (2019). Repurposing suramin for the treatment of breast cancer lung metastasis with glycol chitosan-based nanoparticles. Acta Biomater 84, 378-390.

13. Myers, Charles, Michael Cooper, Cy Stein, Renato LaRocca, M. M. Walther, Gary Weiss, Peter Choyke, Nancy Dawson, Seth Steinberg, and Margaret M. Uhrich. "Suramin: a novel growth factor antagonist with activity in hormone-refractory metastatic prostate cancer." Journal of clinical oncology 10, no. 6 (1992): 881-889.

14.Stein, C. A., R. V. LaRocca, R. Thomas, N. McAtee, and Charles E. Myers. "Suramin: an anticancer drug with a unique mechanism of action." Journal of Clinical Oncology 7, no. 4 (1989): 499-508.

15.Mooon, Jeong-jo, Young-bok Han, and Jin-suk Kim. "Studies on antitumor effects of pine needles, Pinus densiflora Sieb. et Zucc." Korean Journal of Veterinary Research 33, no. 4 (1993): 701-710.

16.Spigelman, Zachary, Amy Dowers, Susan Kennedy, Dennis DiSorbo, Michael O'Brien, Ronald Barr, and Ronald McCaffrey. "Antiproliferative effects of suramin on lymphoid cells." Cancer research 47, no. 17 (1987): 4694-4698.

17.Kathir, Karuppanan Muthusamy, Thallapuranam Krishnaswamy S. Kumar, and Chin Yu. "Understanding the mechanism of the antimitogenic activity of suramin." Biochemistry 45, no. 3 (2006): 899-906

18.https://pubchem.ncbi.nlm.nih.gov/compound/Suramin-sodium

19. Hosang, Markus. "Suramin binds to platelet‐derived growth factor and inhibits its biological activity." Journal of cellular biochemistry 29, no. 3 (1985): 265-273.

20. Betsholtz, Christer, Ann Johnsson, Carl-Henrik Heldin, and Bengt Westermark. "Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin." Proceedings of the National Academy of Sciences 83, no. 17 (1986): 6440-6444.

21. Coffey Jr, Robert J., Edward B. Leof, Gary D. Shipley, and Harold L. Moses. "Suramin inhibition of growth factor receptor binding and mitogenicity in AKR‐2B cells." Journal of cellular physiology 132, no. 1 (1987): 143-148.

22. Sartor, Oliver, Catherine A. McLellan, Charles E. Myers, and M. M. Borner. "Suramin rapidly alters cellular tyrosine phosphorylation in prostate cancer cell lines." The Journal of clinical investigation 90, no. 6 (1992): 2166-2174.

 

 

Depending on how you use these EXTRACTS, at what doses you decide on for your needs - and whether use is for  DISRUPTING SPIKE PROTEINS post mrna shot(s) at 2 Dropperfuls 2X daily ..

Or for purposes of  warding off shedding of spike protein from being in proximity of the heavily vaccinated at 1 Dropperful 2X daily ...

1 bottle of Pine Needle &  1 bottle of Dandelion Extract at max. suggested doses would last 2.5 weeks roughly for 1 adult, or, for warding off adverse spike protein effects after shots – If using the lowest suggested dropperfuls each would last about 4 weeks

The Chlorophyll would last 1 adult about 12 weeks using 1/4 dropperful to every glass of water you drink daily ....

The duration of use for these Extracts:

Use as long as you can for best results. The benefits cumulate. 3 MONTHS IS THE MINIMUM SUGGESTED DURATION. 

Sadly, with the way the spike protein continues to be produced by the body after these shots - using these as long as possible is the best advice protocol.

A study published in the journal Proteomics Clinical Applications on August 31, 2023, found persistence of spike protein in the blood of people who received mRNA COVID‑19 vaccines at six months after vaccination. Source: https://onlinelibrary.wiley.com/doi/10.1002/prca.202300048

Which equates to continuance of spike protein adverse effects and shedding issues. 

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